8 min readLast updated: February 2026

Understanding Mood Changes During Perimenopause

Explore the causes, natural remedies, and lifestyle tips to navigate the complexities of mood fluctuations and foster emotional well-being during perimenopause.

Symptom Overview

Mood disorders, encompassing conditions like depression and bipolar disorder, significantly impact an individual's emotional state. Depression can manifest as persistent sadness and anxiety, while bipolar disorder is characterized by extreme mood swings, oscillating between profound sadness, irritability, and intense happiness. These conditions are observed more frequently in women. It is crucial to recognize that mood disorders can elevate the risk of suicidal thoughts, particularly when severe or co-occurring with substance abuse issues.

Causes of Mood Changes

Mood disorders arise from a complex interplay of genetic predispositions, environmental factors, and significant life events. Environmental influences can include early childhood experiences and exposure to stressful situations. Additionally, certain prescription medications, such as corticosteroids and Parkinson's disease drugs, as well as illicit substances, can induce or exacerbate mood disorders.

Natural Remedies and Lifestyle Tips

While not a substitute for professional medical advice, several natural remedies and lifestyle adjustments may support mood management. It is imperative to consult with a healthcare provider before incorporating any supplements, especially due to potential interactions with existing medications.

Supplements with Potential Benefits:

  • St. John's Wort: 900-1,200mg daily for mild to moderate depression. Caution: significant drug interactions possible.
  • SAMe: 400-800mg daily may improve depressive symptoms and energy levels.
  • Omega-3 Fatty Acids: 2,000-4,000mg daily for depression management.
  • B Vitamins: Essential for nervous system health and mood stability.
  • Vitamin D: May help with seasonal affective disorder.

Lifestyle Adjustments

  • Physical Activity: Regular exercise stimulates endorphin release and improves mood.
  • Nutrition: Balanced diet supports mental health and mood regulation.
  • Sleep Hygiene: Quality sleep is fundamental for emotional stability.
  • Nature & Mindfulness: Time in nature and mind-body practices reduce stress and enhance mood.

When to See a Doctor

Seek professional help if:

  • Emotional difficulties impair work, relationships, or social engagement
  • Concerns about alcohol or drug use
  • Any thoughts of self-harm (call 988 Suicide & Crisis Lifeline immediately)
  • Symptoms persist or worsen despite lifestyle changes

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